Microsoft released the first beta of the Visual Studio LightSwitch IDE earlier this week. It’s designed to allow non-programmers create business applications and allow programmers of various levels to create applications quickly. It simplifies the process and allows doing many common functions like coding a database interaction to be done from a visual perspective. If you need to code anything, you can choose between Visual Basic .NET or C#. The overall goal seems to be allowing one to focus on the business rules and policies while creating an app, not the syntax.
For a quick (a minute and a half) look at Visual Studio LightSwitch, you can watch this video Microsoft has created.
For a walkthrough of building a first application with LightSwitch, you can find step-by-step instructions with this article on a MSDN blog by Jason Zanders.