Connecting a copier to perform its scan-to-email function using Office 365 is not too difficult if you know the right settings.
Microsoft has an Exchange TechNet article on ‘How to Allow a Multi-function Device or Application to Send E-mail through Office 365 Using SMTP‘ which provides three options for creating the connection: SMTP Relay, Client SMTP Submission, and Direct Send.
Unless you already have an SMTP Relay setup in your environment and your device supports TLS, the Client SMTP Submission is the easiest route to take while still offering full features. I configured a Konica Minolta bizhub 36 to send to Office 365 and found the following settings to work reliably.
Logged in as an administrator, under the Network tab you will find E-mail Settings and E-mail TX (SMTP). The settings in here will need to be configured properly to point to Office 365.
Scan to E-mail: Enable
SMTP Server Address: smtp.office365.com
Port Number: 587
SSL/TLS: Start TLS
Device E-mail address: a fully authenticating Office 365 account
SMTP Authentication: Enable
Account: Same email address as Device E-mail address
Password: password for the specified Office 365 account
Your mileage may vary with different devices and models but those settings should work with TLS-capable scan-to-email devices.